The new anticancer era: Tumor metabolism targeting
نویسندگان
چکیده
منابع مشابه
Metabolic targeting as an anticancer strategy: dawn of a new era?
As a result of a spectrum of mitochondrial defects, tumor cells often preferentially use glycolysis to generate adenosine triphosphate (ATP), even in the presence of oxygen, a phenomenon known as aerobic glycolysis, or the "Warburg effect." Dichloroacetate (DCA) is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK), which inhibits pyruvate dehydrogenase (PDH), a gatekeeping enzym...
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Over the last century, a broader interest in the topic of tumor metabolism has emerged. From the 1920s onward, when Otto Warburg proposed increased aerobic glycolysis of tu‐ mor cells, a deeper understanding has established that tumor cells have an altered metab‐ olism which is directly linked to cancer progression. It was soon discovered that not only do environmental changes lead to alteratio...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2017
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2016.1271635